Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts

K Wictorin, P Brundin, B Gustavii, O Lindvall… - Nature, 1990 - nature.com
human telencephalic neuroblasts implanted into the excitotoxically lesioned striatum of adult
rats … influence of the adult CNS environment and extend axons along major myelinated fibre …

… directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6‐hydroxydopamine lesioned adult rats

K Wictorin, P Brundin, H Sauer… - Journal of …, 1992 - Wiley Online Library
… mammalian central nervous system (CNS) at least for certain types of projection neurons. …
) Reformation of long axon pathways in adult rat central nervous system by human forebrain

Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat

O Isacson, TW Deacon - Neuroscience, 1996 - Elsevier
… also exist in the adult central nervous system, if axonal growth inhibition is … Reformation
of long axon pathways in adult rat central nervous system by human forebrain neuroblasts

Regeneration of adult axons in white matter tracts of the central nervous system

SJA Davies, MT Fitch, SP Memberg, AK Hall… - Nature, 1997 - nature.com
… volumes of dissociated adult rat dorsal root ganglia directly into adult rat CNS pathways.
This … matrix in causing regeneration failure in the adult brain. However, we do not know at …

… xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres

O Isacson, TW Deacon, P Pakzaban, WR Galpern… - Nature medicine, 1995 - nature.com
… in the adult central nervous system (CNS). We transplanted embryonic porcine … Reformation
of long axon pathways in adult rat central nervous system by human forebrain neuroblasts, …

Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate …

DR Wakeman, DE Redmond Jr… - Stem cells …, 2014 - academic.oup.com
… the adult primate brain appeared to retain axonal guidance … Immature fetal VM DA neuroblasts
and other postmitotic VM … of host dopamine axons along the nigrostriatal pathway. Scale …

Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease

CN Svendsen, MA Caldwell, J Shen, MG ter Borg… - Experimental …, 1997 - Elsevier
adult rat brain, often migrating and integrating within host tissues (8, 14, 23, 38) but there are
currently few reports where human neural … of neurons and axonal processes throughout the …

Regeneration and transplantation of the optic nerve: developing a clinical strategy

RE MAcLAREN - British journal of ophthalmology, 1998 - bjo.bmj.com
… independently reformed by an interaction of regrowing axons … = inner neuroblastic layer;
ONL = outer neuroblastic layer) to … able to reform functional connections with host brain targets …

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

G Hargus, O Cooper, M Deleidi… - Proceedings of the …, 2010 - National Acad Sciences
… Morphologically, we found that PDiPS cell-derived non-DA neurons send axonsadult brain.
Such findings establish the transplantation of human PDiPS cell-derived neurons as a long-…

Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats

O Brüstle, K Choudhary, K Karram, A Hüttner… - Nature …, 1998 - nature.com
… for the understanding of human central nervous system (CNS) … transplanted human
oligodendrocytes myelinate host axons. … appear to follow endogenous migratory routes. For …